Archive for June, 2011

Is Flaxseed Good for You?

I was asked this question the other evening, so I had to do some research. The questioner was interested in a possible use for cancer. Obviously, we cannot say that anything will cure cancer. However, asking if a product will help is a good question. This post is the result of my initial research.

A photo of one kind of flaxseedsThe Mayo Clinic says that flaxseed contains some things that your body needs. These things include fiber (you know that is good for you, right?), omega-3 fatty acids (also helpful), and some chemicals called lignans.

So what exactly are lignans? My training as a pharmacist tells me that they have a very complex chemical structure, which I am not going to repeat here. Lignans are found in many plant products, although the greatest amounts are found in flaxseed and sesame seeds. The active ingredient is called secoisolariciresinal diglucoside, which usually gets shortened to SDG. SDG is broken down in the body, where it reacts with special structures called estrogen receptors (they come to life when the hormone estrogen becomes attached to them). This SDG is what has been investigated for possible anticancer effects in a number of clinical and animal studies.

Some types of cancer may respond to increased eating of flax seeds, but much of the research that shows up on PubMed (an index of articles that discuss treatments for diseases) is in mice or rats. Whether the findings in humans will match those in animals remains to be seen. The particular types of cancer that have been investigated include breast, colon, prostate, and skin. It appears that taking flax seed or that SDG that we talked about above, may be best in the very early stages of cancer, but again don’t stop taking the medicine that your doctor prescribes if you have been diagnosed with any of these diseases.

A recent study, published by Dr. Hijova and colleagues, from Safarikiensis University in Slovakia, was particularly interesting, so I took a look at the full article. These researchers gave rats a high-fat diet and then gave them a prebiotic alone or in combination with horse chestnut extract or flaxseed oil. Another group of animals got the prebiotic and both horse chestnut extract and flaxseed oil. What they found was that in the animals that got the treatments there was a reduction in concentrations of an enzyme that they say has been found to be increased in patients with colon cancer. There were also reductions in total cholesterol, triacylglycerols, and bile acids compared with animals that got only the prebiotic.

The design of this study doesn’t allow us to draw any conclusions about whether the same thing will happen in humans. The authors make a very valid point in their conclusion, however. That is that diet may be very important in prevention of disease, and the role of nutritional supplements, like flaxseed oil and horse chestnut extract, needs to be studied in the future.

Looking at the research that has been conducted that flaxseed or the oil that comes from the seeds may be helpful in improving the chances of medications working in a number of different areas. It appears that flaxseed may be good for you, with little risk of side effects. Of course, check with your doctor before taking flaxseed for any ‘medicinal’ purposes.

I recently saw an article on PubMed that suggested that acupuncture may help improve some of the symptoms of sleep apnea. The study, published in Chinese, suggests that the apnea-hypopnea index (AHI), and the oxygen desaturation index (ODI) were reduced, and oxygen saturation of the blood were both improved after 3 to 5 sessions of acupuncture each week until 30 sessions had been completed. Unfortunately, there were only 30 patients enrolled in this study, so the evidence that acupuncture may be beneficial for sleep apnea is not very strong.

Unfortunately, when I searched PubMed for other studies that looked at acupuncture and apnea, there was only one other study, conducted by the same group, in which 12 patients were actually treated with acupuncture. In this study, the patients were treated once a week for 10 weeks. As in the more recent study, the AHI improved in patients who got acupuncture. There was also a control group who got no treatment – in these patients the AHI deteriorated.

These two studies in people with sleep apnea suggest that it may be worth trying acupuncture to reduce the effect of sleep apnea. However, the number of patients is small, and you need to have at least 10 and up to 30 sessions to show the kind of effects that were seen in these studies. Clearly, more research will be needed before acupuncture can be used to treat sleep apnea. If I was able to find an acupuncturist who could do this, I would want to have another sleep study after the treatment session before I turned off my CPAP machine. Also, I would want to have a follow-up study 6-12 months after the course of acupuncture to make sure that the apnea had not become worse.

Do you or someone you know have sleep apnea? There is a stereotype that says that you have to be overweight, over 40, and a guy. However, the reality is that apnea can affect anyone. The usual symptoms include daytime sleepiness, waking up in the middle of the night gasping for breath or needing to use the bathroom. Snoring is often a sign that people think is associated with sleep apnea, but not everyone with apnea does snore, and not everyone who snores has sleep apnea. The only way to accurately measure apnea is with a painless sleep study. You are wired up with various recording systems, but once you are asleep you don’t notice. The standard indicator of severity of apnea is the apnea-hypopnea index (the AHI that I mentioned above).

The AHI is simply a measure of the number of times each hour that you stop breathing for more than 10-20 seconds (apnea) or have restricted breathing where your airway is not completely obstructed (hypopnea). My AHI was 31 times per hour before I got treated with CPAP. After more than 18 months of wearing a mask every night, it is now 2 times per hour (sometimes less, sometimes more).